Endocrine Abstracts

Bile acids are endocrine molecules that in addition to facilitating the absorption of fat-soluble nutrients regulate numerous metabolic processes, including glucose, lipid, and energy homeostasis. The actions of bile acids are mediated through specific bile acid-activated nuclear and membrane bound receptors such as farnesoid X receptor (FXR) and G protein-coupled receptor 5 (TGR5). Bile acid signaling is modified by interactions with gut bacteria which metabolize primary bile...